MAP3K4-AS1

Across TCGA pan-cancer cohorts, MAP3K4-AS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MAP3K4-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MAP3K4-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MAP3K4-AS1 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

HNSC, COAD, and STAD are the cancer types where MAP3K4-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAP3K4-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.735	<.001	11	view →
COAD	All	III,IV	+0.846	<.001	9	view →
STAD	Male	II,III,IV	+0.864	.005	7	view →
KICH	All	All	−0.739	<.001	7	view →
LIHC	Female	All	+0.233	<.001	7	view →
BRCA	All	III,IV	+1.274	<.001	6	view →
LUSC	Female	All	+1.237	<.001	5	view →
CHOL	All	All	+0.834	.002	5	view →
KIRP	All	IV	+0.812	.025	4	view →
UCEC	All	All	−0.680	.018	2	view →
PRAD	All	All	+0.253	.044	2	view →
KIRC	Male	III,IV	−0.234	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MAP3K4-AS1–HNSC

Open the HNSC breakdown →