MAP3K21

Across TCGA patient cohorts, MAP3K21 protein abundance is significantly associated with the protein abundance of many other proteins, with 3,470 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible MAP3K21-associated proteins across cancer lineages are EPB41L2_S402, GRIP1_S43, and RO60. Each is linked with MAP3K21 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP3K21-to-partner and partner-to-MAP3K21 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MAP3K21 versus EPB41L2_S402 in CCRCC, with a Pearson correlation of -0.46.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K21→partner) and Y-score (partner→MAP3K21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	EPB41L2_S402 →	-0.613	-0.455	.001	.002	3	2
LUAD	GRIP1_S43 →	-1.056	-0.460	<.001	<.001	3	2
PDAC	RO60 →	-0.202	-0.746	.002	<.001	3	2
PDAC	SH2D3C →	+0.411	+0.917	<.001	<.001	3	2
CCRCC	SLFN5 →	-0.244	-0.375	<.001	<.001	3	2
UCEC	USP24 →	+0.205	+0.498	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,470 associations by consensus.

MAP3K21 vs EPB41L2_S402 — CCRCC

Explore this scatter interactively →