MAP3K21

Across TCGA pan-cancer cohorts, MAP3K21 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of MAP3K21’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where MAP3K21 RNA is repressed in tumor relative to normal tissue. In most cancer types MAP3K21 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, HNSC, and KIRC are the cancer types where MAP3K21 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAP3K21 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	IV	−1.592	<.001	11	view →
HNSC	Male	IV	+1.470	<.001	11	view →
KIRC	All	III,IV	−0.594	<.001	11	view →
BLCA	All	III,IV	+1.416	<.001	10	view →
COAD	All	II,III,IV	+0.573	<.001	7	view →
UCEC	All	All	+1.363	<.001	6	view →
STAD	Male	All	+1.162	<.001	5	view →
LUSC	Male	II,III,IV	+0.892	<.001	5	view →
CHOL	All	All	+3.018	<.001	3	view →
LUAD	Male	All	+0.500	.008	3	view →
READ	Female	All	+0.919	.004	2	view →
KIRP	Male	All	−0.668	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

MAP3K21–KICH

Open the KICH breakdown →