MAP3K21

Across TCGA patient cohorts, MAP3K21 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP3K21-associated genes across cancer lineages are mTOR_pS2448, PCNA, and Cyclin-B1. Each is linked with MAP3K21 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAP3K21-to-partner and partner-to-MAP3K21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by MAP3K21-low versus MAP3K21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K21→partner) and Y-score (partner→MAP3K21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.155	-2.482	.001	.001	3	3
COAD	PCNA →	+0.363	+2.915	<.001	<.001	3	3
UCEC	Cyclin-B1 →	+0.613	+3.000	<.001	<.001	3	3
COAD	ACVRL1 →	-0.192	-3.153	.045	.018	3	3
COAD	TFRC →	+0.489	+2.459	.016	.018	3	3
COAD	ASNS →	+0.531	+3.169	<.001	.017	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

mTOR_pS2448 by MAP3K21 expression — UCEC

Explore this box plot interactively →