MAP3K21

Across TCGA cell cohorts, MAP3K21 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,115 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MAP3K21-associated GO terms across cancer lineages are Positive regulation of telomerase RNA localization to Cajal body, Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator, and Actomyosin contractile ring organization. Each is linked with MAP3K21 in more than 11 cancer types. Because this analysis shows association rather than direction, both MAP3K21-to-partner and partner-to-MAP3K21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of telomerase RNA localization to Cajal body grouped by MAP3K21-low versus MAP3K21-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K21→partner) and Y-score (partner→MAP3K21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of telomerase RNA localization to Cajal body →	+0.120	+1.181	<.001	<.001	3	12
LUNG_SCLC	Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator →	+0.073	+0.749	<.001	.006	3	11
STOMACH	Actomyosin contractile ring organization →	+0.165	+2.029	<.001	<.001	3	11
LARGE_INTESTINE	Nuclear pore complex assembly →	+0.130	+1.198	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	RNA export from nucleus →	+0.112	+1.084	.003	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	scaRNA localization to Cajal body →	+0.097	+1.295	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,115 associations by consensus.

Positive regulation of telomerase RNA localization to Cajal body by MAP3K21 expression — BONE

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