MAP3K20

Across TCGA patient cohorts, MAP3K20 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP3K20-associated genes across cancer lineages are Caspase-7-cleavedD198, MSH2, and mTOR_pS2448. Each is linked with MAP3K20 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAP3K20-to-partner and partner-to-MAP3K20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MAP3K20-low versus MAP3K20-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K20→partner) and Y-score (partner→MAP3K20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.751	+2.479	<.001	<.001	3	3
UCEC	MSH2 →	-0.270	-2.143	<.001	.002	3	2
UCEC	mTOR_pS2448 →	-0.121	-2.067	.007	.005	3	2
UCEC	Notch1 →	+0.164	+2.080	<.001	<.001	3	2
UCEC	PCNA →	+0.236	+1.999	<.001	<.001	3	2
UCEC	Rictor_pT1135 →	-0.078	-1.321	.011	.012	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Caspase-7-cleavedD198 by MAP3K20 expression — UCEC

Explore this box plot interactively →