MAP3K20

Across TCGA cell cohorts, MAP3K20 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,420 significant associations in total. BONE shows the largest number of these associations.

The most reproducible MAP3K20-associated GO terms across cancer lineages are GCN2-mediated signaling, Positive regulation of focal adhesion assembly, and Regulation of stress-activated protein kinase signaling cascade. Each is linked with MAP3K20 in more than 16 cancer types. Because this analysis shows association rather than direction, both MAP3K20-to-partner and partner-to-MAP3K20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GCN2-mediated signaling grouped by MAP3K20-low versus MAP3K20-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K20→partner) and Y-score (partner→MAP3K20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GCN2-mediated signaling →	+0.193	+1.264	<.001	.006	3	17
BONE	Positive regulation of focal adhesion assembly →	+0.226	+0.980	<.001	<.001	3	15
LIVER	Regulation of stress-activated protein kinase signaling cascade →	+0.136	+1.322	.001	<.001	3	15
BONE	Regulation of cell-substrate junction assembly →	+0.176	+1.067	<.001	<.001	3	14
BONE	Regulation of focal adhesion assembly →	+0.176	+1.067	<.001	<.001	3	14
BONE	Regulation of cell-substrate junction organization →	+0.162	+1.425	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,420 associations by consensus.

GCN2-mediated signaling by MAP3K20 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →