MAP3K2

Across TCGA patient cohorts, MAP3K2 mutation is significantly associated with the RNA expression of many other genes, with 2,681 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP3K2-associated genes across cancer lineages are MIR6784, H2AC12, and LINC01730. Each is linked with MAP3K2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP3K2-to-partner and partner-to-MAP3K2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6784 grouped by MAP3K2-low versus MAP3K2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K2→partner) and Y-score (partner→MAP3K2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR6784 →	+0.494	+2.345	<.001	.007	3	2
UCEC	H2AC12 →	+0.571	+1.960	<.001	.008	3	2
UCEC	LINC01730 →	+0.345	+2.455	<.001	.001	3	2
UCEC	GTSE1-DT →	+0.449	+2.664	<.001	<.001	3	2
SKCM	PRDX4P1 →	+0.029	+4.640	<.001	.003	3	2
LIHC	RNU6-1214P →	+0.369	+6.169	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,681 associations by consensus.

MIR6784 by MAP3K2 expression — SKCM

Explore this box plot interactively →