MAP3K13

Across TCGA patient cohorts, MAP3K13 mutation is significantly associated with the RNA expression of many other genes, with 5,633 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP3K13-associated genes across cancer lineages are NDUFB4, NDUFC1, and RNF7. Each is linked with MAP3K13 in more than 3 cancer types. Because this analysis shows association rather than direction, both MAP3K13-to-partner and partner-to-MAP3K13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFB4 grouped by MAP3K13-low versus MAP3K13-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K13→partner) and Y-score (partner→MAP3K13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NDUFB4 →	+0.441	+3.372	<.001	.004	3	4
UCEC	NDUFC1 →	+0.269	+1.301	.002	.002	3	4
UCEC	RNF7 →	+0.191	+2.209	.004	<.001	3	4
BLCA	OR5BH1P →	+0.215	+3.234	.001	.001	3	3
UCEC	EIF4E →	+0.383	+2.158	<.001	<.001	3	3
UCEC	PKN3 →	+0.756	+1.936	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,633 associations by consensus.

NDUFB4 by MAP3K13 expression — SKCM

Explore this box plot interactively →