MAP3K13

Across TCGA pan-cancer cohorts, MAP3K13 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated MAP3K13 data layer compared with 6 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher MAP3K13 RNA is associated with better overall survival. In most high-consensus cancer types, elevated MAP3K13 expression acts as an unfavorable survival marker, although some lineages such as UVM and KIRC show a favorable association.

UVM, KIRC, and PAAD are the cancer types where MAP3K13 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.794	0.435	<.001	80	view →
KIRC	OS	Median	All	0.709	0.548	<.001	73	view →
PAAD	OS	Median	All	0.280	0.495	.001	60	view →
ACC	DFS	Median	All	0.243	0.635	<.001	59	view →
OV	OS	Tertile	II,III,IV	0.453	0.325	.004	58	view →
KICH	DFS	Tertile	II,III,IV	0.577	1.000	.002	44	view →
LUSC	OS	Quartile	All	0.811	0.689	.001	31	view →
LAML	DFS	Median	All	0.430	0.704	.006	24	view →
ESCA	OS	Tertile	IV	0.143	0.738	.024	18	view →
UCS	DFS	Quartile	II,III,IV	0.553	0.159	.001	18	view →
LGG	DFS	Quartile	All	0.875	0.699	.003	10	view →
STAD	OS	Median	II,III,IV	0.488	0.365	.035	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

MAP3K13–UVM (OS)

Open the UVM breakdown →