MAP3K13

Across TCGA patient cohorts, MAP3K13 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP3K13-associated genes across cancer lineages are p90 RSK_pT359_S363, Src_pY527, and eEF2. Each is linked with MAP3K13 in more than 3 cancer types. Because this analysis shows association rather than direction, both MAP3K13-to-partner and partner-to-MAP3K13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p90 RSK_pT359_S363 grouped by MAP3K13-low versus MAP3K13-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K13→partner) and Y-score (partner→MAP3K13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	p90 RSK_pT359_S363 →	-0.288	-3.000	<.001	.036	3	4
BLCA	Src_pY527 →	-0.593	-3.000	.028	.036	3	3
SKCM	eEF2 →	+0.392	+2.824	.013	.034	3	3
UCEC	MEK1 →	+0.359	+2.662	<.001	<.001	3	3
UCEC	mTOR_pS2448 →	-0.126	-1.398	.002	.004	3	3
UCEC	PKC-delta_pS664 →	-0.081	-1.440	.017	.020	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

p90 RSK_pT359_S363 by MAP3K13 expression — BLCA

Explore this box plot interactively →