MAP3K13

Across TCGA cell cohorts, MAP3K13 mutation is significantly associated with the RNA expression of many other genes, with 81 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAP3K13-associated genes across cancer lineages are PRAC1, OR10K2, and OR10T2. Each is linked with MAP3K13 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP3K13-to-partner and partner-to-MAP3K13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAC1 grouped by MAP3K13-low versus MAP3K13-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K13→partner) and Y-score (partner→MAP3K13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PRAC1 →	+0.253	+4.064	<.001	.003	3	2
BLOOD_Leukemia	OR10K2 →	+0.060	+4.705	<.001	.003	3	2
BLOOD_Leukemia	OR10T2 →	+0.889	+4.276	<.001	.007	3	2
SOFT_TISSUE	NPVF →	+0.012	+4.930	.003	.008	3	1
KIDNEY	TRH →	+0.015	+4.222	<.001	.001	3	1
BLOOD_Leukemia	GFRA4 →	+0.308	+4.409	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 81 associations by consensus.

PRAC1 by MAP3K13 expression — BREAST

Explore this box plot interactively →