MAP3K11

Across TCGA patient cohorts, MAP3K11 mutation is significantly associated with the RNA expression of many other genes, with 1,221 significant associations in total. COAD shows the largest number of these associations.

The most reproducible MAP3K11-associated genes across cancer lineages are MED14P1, GMEB1, and MAPK12. Each is linked with MAP3K11 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAP3K11-to-partner and partner-to-MAP3K11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MED14P1 grouped by MAP3K11-low versus MAP3K11-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K11→partner) and Y-score (partner→MAP3K11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MED14P1 →	+0.046	+8.057	<.001	.005	3	3
COAD	GMEB1 →	+0.441	+3.472	<.001	.002	3	3
UCEC	MAPK12 →	+0.790	+2.815	<.001	.001	3	3
STAD	RN7SKP186 →	+0.196	+3.203	<.001	.002	3	3
COAD	RN7SL418P →	+0.339	+3.666	<.001	.002	3	2
LIHC	RNU6-16P →	+0.585	+3.261	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,221 associations by consensus.

MED14P1 by MAP3K11 expression — BRCA

Explore this box plot interactively →