MAP3K10

Across TCGA patient cohorts, MAP3K10 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP3K10-associated genes across cancer lineages are EGFR, ERK2, and Ku80. Each is linked with MAP3K10 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP3K10-to-partner and partner-to-MAP3K10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by MAP3K10-low versus MAP3K10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K10→partner) and Y-score (partner→MAP3K10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.128	-1.247	.018	.045	3	1
UCEC	ERK2 →	+0.166	+2.807	.011	.002	3	1
UCEC	Ku80 →	+0.204	+1.820	.011	.014	3	1
UCEC	MSH2 →	-0.201	-1.674	.010	.040	3	1
UCEC	Notch1 →	+0.098	+1.514	.041	.015	3	1
UCEC	Rab11 →	-0.106	-1.514	.031	.015	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

EGFR by MAP3K10 expression — UCEC

Explore this box plot interactively →