MAP3K10

Across TCGA pan-cancer cohorts, MAP3K10 RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated MAP3K10 data layer compared with 5 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher MAP3K10 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MAP3K10 expression acts as an unfavorable survival marker, although some lineages such as BLCA and HNSC show a favorable association.

UVM, KIRC, and ACC are the cancer types where MAP3K10 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Quartile	All	0.435	0.774	.005	62	view →
KIRC	DFS	Quartile	II,III,IV	0.381	0.661	.004	58	view →
ACC	DFS	Quartile	All	0.334	0.785	<.001	56	view →
MESO	OS	Quartile	II,III,IV	0.237	0.486	.008	56	view →
BLCA	OS	Quartile	All	0.763	0.582	.003	36	view →
THCA	OS	Median	II,III,IV	0.904	0.987	.003	29	view →
LIHC	DFS	Tertile	All	0.448	0.617	<.001	25	view →
COAD	OS	Tertile	II,III,IV	0.657	0.851	.005	24	view →
HNSC	OS	Tertile	III,IV	0.489	0.310	.008	20	view →
OV	OS	Median	All	0.782	0.897	<.001	18	view →
ESCA	DFS	Median	IV	0.634	0.205	.006	18	view →
SCLC	OS	Tertile	All	0.806	0.593	.012	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

MAP3K10–UVM (OS)

Open the UVM breakdown →