MAP3K10

Across TCGA cell cohorts, MAP3K10 mutation is significantly associated with the RNA expression of many other genes, with 182 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAP3K10-associated genes across cancer lineages are SSX7, PRDM7, and PRKX. Each is linked with MAP3K10 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP3K10-to-partner and partner-to-MAP3K10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SSX7 grouped by MAP3K10-low versus MAP3K10-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K10→partner) and Y-score (partner→MAP3K10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SSX7 →	+0.022	+5.369	<.001	.004	3	2
LARGE_INTESTINE	PRDM7 →	+0.162	+2.369	<.001	.003	3	2
LARGE_INTESTINE	PRKX →	+0.790	+3.067	.002	.009	3	2
SKIN	MYOCD →	+0.615	+3.257	.008	.001	3	2
SOFT_TISSUE	C20orf85 →	+0.115	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR1L4 →	+0.072	+5.369	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 182 associations by consensus.

SSX7 by MAP3K10 expression — SOFT_TISSUE

Explore this box plot interactively →