MAP3K1

Across TCGA patient cohorts, MAP3K1 protein abundance is significantly associated with the protein abundance of many other proteins, with 7,763 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible MAP3K1-associated proteins across cancer lineages are KMT2E_S845, ACTR8_S132, and SLC25A13. Each is linked with MAP3K1 in more than 3 cancer types. Because this analysis shows association rather than direction, both MAP3K1-to-partner and partner-to-MAP3K1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MAP3K1 versus KMT2E_S845 in BRCA, with a Pearson correlation of 0.46.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K1→partner) and Y-score (partner→MAP3K1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KMT2E_S845 →	+0.754	+0.345	.001	.002	3	3
GBM	ACTR8_S132 →	+0.378	+0.343	<.001	<.001	3	2
BRCA	SLC25A13 →	-0.438	-0.369	.003	.001	3	2
HNSC	SMC2 →	-0.413	-0.433	<.001	<.001	3	2
BRCA	SRPK2_S10 →	+0.751	+0.270	.003	.003	3	2
BRCA	SSBP2 →	+0.550	+0.267	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,763 associations by consensus.

MAP3K1 vs KMT2E_S845 — BRCA

Explore this scatter interactively →