MAP2K6

Across TCGA patient cohorts, MAP2K6 mutation is significantly associated with the RNA expression of many other genes, with 2,620 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP2K6-associated genes across cancer lineages are PRAMEF11, RNU6-993P, and EDC3. Each is linked with MAP2K6 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP2K6-to-partner and partner-to-MAP2K6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF11 grouped by MAP2K6-low versus MAP2K6-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP2K6→partner) and Y-score (partner→MAP2K6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	PRAMEF11 →	+0.021	+5.969	.009	.002	3	2
CESC	RNU6-993P →	+0.356	+5.812	<.001	.003	3	2
UCEC	EDC3 →	+0.289	+1.545	.001	.005	3	2
UCEC	ARID3B →	+0.312	+2.431	.004	.001	3	2
UCEC	PCBP1-AS1 →	+0.388	+2.386	<.001	.002	3	2
UCEC	LSM10 →	+0.295	+2.346	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,620 associations by consensus.

PRAMEF11 by MAP2K6 expression — CESC

Explore this box plot interactively →