MAP2K6

Across TCGA pan-cancer cohorts, MAP2K6 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated MAP2K6 data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher MAP2K6 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MAP2K6 expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

UVM, KIRC, and BRCA are the cancer types where MAP2K6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	III,IV	0.305	0.764	<.001	119	view →
KIRC	DFS	Tertile	All	0.725	0.550	<.001	114	view →
BRCA	DFS	Tertile	All	0.969	0.919	<.001	103	view →
LUAD	DFS	Quartile	III,IV	0.306	0.667	.001	52	view →
LIHC	OS	Tertile	All	0.677	0.846	<.001	41	view →
PAAD	OS	Median	All	0.569	0.397	.007	25	view →
LUSC	OS	Quartile	All	0.749	0.584	.003	23	view →
SCLC	DFS	Tertile	III,IV	0.216	0.664	.005	17	view →
OV	DFS	Quartile	IV	0.516	0.220	.008	16	view →
LGG	DFS	Tertile	All	0.631	0.422	<.001	14	view →
THYM	OS	Median	All	1.000	0.654	.005	9	view →
KICH	DFS	Quartile	III,IV	0.263	1.000	.032	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

MAP2K6–UVM (DFS)

Open the UVM breakdown →