MAP2K6

Across TCGA patient cohorts, MAP2K6 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP2K6-associated genes across cancer lineages are p62 Lck ligand, ASNS, and ATM. Each is linked with MAP2K6 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP2K6-to-partner and partner-to-MAP2K6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by MAP2K6-low versus MAP2K6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP2K6→partner) and Y-score (partner→MAP2K6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.333	+2.916	.003	<.001	3	2
UCEC	ASNS →	+0.305	+1.584	.015	.034	3	2
UCEC	ATM →	-0.558	-2.321	<.001	.005	3	2
UCEC	14-3-3_beta →	-0.101	-3.673	.003	.001	3	1
UCEC	eIF4E →	+0.215	+3.087	.003	<.001	3	1
UCEC	A-Raf_pS299 →	-0.122	-2.000	.003	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

p62 Lck ligand by MAP2K6 expression — UCEC

Explore this box plot interactively →