MAP2K4

Across TCGA patient cohorts, MAP2K4 protein abundance is significantly associated with the RNA expression of many other genes, with 10,390 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible MAP2K4-associated genes across cancer lineages are RABEP1, PAFAH1B1, and MPDU1. Each is linked with MAP2K4 in more than 5 cancer types. Because this analysis shows association rather than direction, both MAP2K4-to-partner and partner-to-MAP2K4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MAP2K4 versus RABEP1 in BRCA, with a Pearson correlation of 0.53.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP2K4→partner) and Y-score (partner→MAP2K4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RABEP1 →	+1.127	+0.437	<.001	<.001	3	6
OV	PAFAH1B1 →	+0.678	+0.216	<.001	<.001	3	6
COAD	MPDU1 →	+0.592	+0.185	.007	.002	3	5
LUAD	ADPRM →	+0.522	+0.186	<.001	<.001	3	5
BRCA	TOM1L2 →	+0.854	+0.511	<.001	<.001	3	5
BRCA	HPN →	+1.496	+0.324	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,390 associations by consensus.

MAP2K4 vs RABEP1 — BRCA

Explore this scatter interactively →