MAP2K4

Across TCGA patient cohorts, MAP2K4 mutation is significantly associated with the RNA expression of many other genes, with 3,249 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP2K4-associated genes across cancer lineages are GABRE, SLC1A4, and ALG2. Each is linked with MAP2K4 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAP2K4-to-partner and partner-to-MAP2K4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GABRE grouped by MAP2K4-low versus MAP2K4-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP2K4→partner) and Y-score (partner→MAP2K4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GABRE →	-0.714	-2.132	.007	.004	3	3
BRCA	SLC1A4 →	+0.635	+3.332	.005	.005	3	3
BRCA	ALG2 →	+0.311	+2.717	.006	<.001	3	3
UCEC	TCTN3 →	+0.421	+2.110	<.001	<.001	3	3
UCEC	MRFAP1 →	+0.368	+2.145	.001	<.001	3	3
UCEC	BLOC1S2 →	+0.323	+2.555	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,249 associations by consensus.

GABRE by MAP2K4 expression — BRCA

Explore this box plot interactively →