MAP2K2

Across TCGA patient cohorts, MAP2K2 protein abundance is significantly associated with the RNA expression of many other genes, with 9,259 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible MAP2K2-associated genes across cancer lineages are ZNF430, ZNF440, and ZNF431. Each is linked with MAP2K2 in more than 3 cancer types. Because this analysis shows association rather than direction, both MAP2K2-to-partner and partner-to-MAP2K2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MAP2K2 versus ZNF430 in BRCA, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP2K2→partner) and Y-score (partner→MAP2K2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZNF430 →	+0.487	+0.171	<.001	<.001	3	4
LSCC	ZNF440 →	+0.649	+0.192	<.001	.001	3	4
LUAD	ZNF431 →	+0.550	+0.147	.006	.008	3	4
BRCA	ZNF253 →	+0.522	+0.162	<.001	<.001	3	4
LSCC	PDIA6 →	-0.462	-0.181	<.001	<.001	3	3
COAD	HSP90B1 →	-0.385	-0.139	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,259 associations by consensus.

MAP2K2 vs ZNF430 — BRCA

Explore this scatter interactively →