MAP2K1

Across TCGA cell cohorts, MAP2K1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MAP2K1-associated genes across cancer lineages are UCN3, TFAP2D, and SMR3B. Each is linked with MAP2K1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP2K1-to-partner and partner-to-MAP2K1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UCN3 grouped by MAP2K1-low versus MAP2K1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP2K1→partner) and Y-score (partner→MAP2K1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	UCN3 →	+0.055	+4.977	<.001	.007	3	1
SKIN	TFAP2D →	+0.189	+5.415	<.001	.004	3	1
LARGE_INTESTINE	SMR3B →	+0.968	+4.467	<.001	.004	3	1
LARGE_INTESTINE	OR4F4 →	+0.017	+4.273	.001	.006	3	1
BLOOD_Leukemia	GNGT1 →	+0.055	+3.551	<.001	.009	3	1
BLOOD_Leukemia	NPFFR1 →	+0.011	+4.037	.003	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

UCN3 by MAP2K1 expression — SKIN

Explore this box plot interactively →