MAP2

Across TCGA patient cohorts, MAP2 mutation is significantly associated with the RNA expression of many other genes, with 7,177 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP2-associated genes across cancer lineages are TYMSOS, NDUFA12, and RMDN2. Each is linked with MAP2 in more than 4 cancer types. Because this analysis shows association rather than direction, both MAP2-to-partner and partner-to-MAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TYMSOS grouped by MAP2-low versus MAP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP2→partner) and Y-score (partner→MAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TYMSOS →	+0.876	+2.288	<.001	<.001	3	5
UCEC	NDUFA12 →	+0.196	+1.869	.006	.004	3	5
CESC	RMDN2 →	-0.459	-2.690	.001	.006	3	4
STAD	KLHDC1 →	-0.399	-2.037	.001	.001	3	4
UCEC	ZIC2 →	+1.490	+2.090	<.001	<.001	3	4
LUAD	POLE2 →	+0.615	+3.169	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,177 associations by consensus.

TYMSOS by MAP2 expression — UCEC

Explore this box plot interactively →