MAP2

Across TCGA cell cohorts, MAP2 mutation is significantly associated with the mutation status of many other genes, with 3,657 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAP2-associated genes across cancer lineages are IGSF10, PLXNB1, and DCDC1. Each is linked with MAP2 in more than 5 cancer types. Because this analysis shows association rather than direction, both MAP2-to-partner and partner-to-MAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGSF10 grouped by MAP2-low versus MAP2-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP2→partner) and Y-score (partner→MAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	IGSF10 →	+3.938	+3.263	.002	.002	1	6
SOFT_TISSUE	PLXNB1 →	+5.066	+4.502	.007	.007	1	6
LUNG_NSCLC_LUSC	DCDC1 →	+3.938	+3.263	.002	.002	1	6
LUNG_NSCLC_LUAD	EPHA7 →	+2.959	+2.266	.003	.003	1	6
BLOOD_Lymphoma	GPR179 →	+2.753	+2.753	.002	.002	1	6
SOFT_TISSUE	ZNF407 →	+5.066	+4.502	.007	.007	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,657 associations by consensus.

IGSF10 by MAP2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →