MAP1LC3A

Across TCGA patient cohorts, MAP1LC3A mutation is significantly associated with the RNA expression of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP1LC3A-associated genes across cancer lineages are NMNAT1P5, DNM1P31, and RNU5A-2P. Each is linked with MAP1LC3A in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP1LC3A-to-partner and partner-to-MAP1LC3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NMNAT1P5 grouped by MAP1LC3A-low versus MAP1LC3A-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP1LC3A→partner) and Y-score (partner→MAP1LC3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	NMNAT1P5 →	+0.033	+4.704	.001	.005	3	2
BLCA	DNM1P31 →	+0.045	+6.466	<.001	<.001	3	1
COAD	RNU5A-2P →	+0.419	+6.003	<.001	.002	3	1
COAD	MIR30B →	+0.527	+6.122	<.001	.002	3	1
COAD	WDR7-OT1 →	+0.101	+5.693	<.001	.003	3	1
BLCA	RNU4-4P →	+0.476	+4.450	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

NMNAT1P5 by MAP1LC3A expression — BLCA

Explore this box plot interactively →