MAP1A

Across TCGA patient cohorts, MAP1A mutation is significantly associated with the total protein of many other genes, with 74 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP1A-associated genes across cancer lineages are ER-alpha, eIF4E, and FoxM1. Each is linked with MAP1A in more than 3 cancer types. Because this analysis shows association rather than direction, both MAP1A-to-partner and partner-to-MAP1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-alpha grouped by MAP1A-low versus MAP1A-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP1A→partner) and Y-score (partner→MAP1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ER-alpha →	-0.178	-3.000	.027	.034	3	4
UCEC	eIF4E →	+0.222	+1.887	<.001	<.001	3	4
LUSC	FoxM1 →	+0.294	+2.459	.010	.018	2	4
LUSC	p62 Lck ligand →	+0.575	+2.009	.014	.018	3	3
BRCA	S6 →	+0.330	+3.005	.035	.020	3	3
BRCA	53BP1 →	+0.319	+2.115	.027	.020	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

ER-alpha by MAP1A expression — STAD

Explore this box plot interactively →