MAP1A

Across TCGA pan-cancer cohorts, MAP1A RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated MAP1A data layer compared with 12 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher MAP1A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MAP1A expression acts as an unfavorable survival marker, although some lineages such as ACC and LGG show a favorable association.

UVM, BLCA, and KICH are the cancer types where MAP1A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.397	0.772	<.001	135	view →
BLCA	OS	Median	All	0.328	0.585	<.001	121	view →
KICH	OS	Median	II,III,IV	0.615	0.964	.002	79	view →
ACC	DFS	Median	III,IV	0.573	0.120	.001	68	view →
OV	OS	Tertile	All	0.790	0.900	<.001	44	view →
LGG	OS	Tertile	All	0.537	0.322	<.001	39	view →
MESO	OS	Tertile	II,III,IV	0.327	0.545	.006	37	view →
THCA	OS	Quartile	All	0.817	0.985	.002	30	view →
DLBC	DFS	Median	IV	1.000	0.412	.006	24	view →
SARC	OS	Quartile	All	0.906	0.579	<.001	21	view →
LUAD	DFS	Quartile	II,III,IV	0.514	0.783	.007	13	view →
THYM	OS	Median	All	0.960	0.769	.004	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

MAP1A–UVM (DFS)

Open the UVM breakdown →