MAP1A

Across TCGA cell cohorts, MAP1A mutation is significantly associated with the RNA expression of many other genes, with 567 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MAP1A-associated genes across cancer lineages are NIPSNAP1, CAPN7, and LRRD1. Each is linked with MAP1A in more than 2 cancer types. Because this analysis shows association rather than direction, both MAP1A-to-partner and partner-to-MAP1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NIPSNAP1 grouped by MAP1A-low versus MAP1A-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP1A→partner) and Y-score (partner→MAP1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NIPSNAP1 →	+0.686	+2.628	.001	.002	3	3
BLOOD_Leukemia	CAPN7 →	+0.428	+3.228	.002	.004	3	3
BLOOD_Leukemia	LRRD1 →	+0.089	+2.285	<.001	.003	3	3
LUNG_NSCLC_LUAD	MAGEB3 →	+0.356	+3.215	<.001	<.001	3	3
LARGE_INTESTINE	LYG1 →	+0.717	+2.364	.002	<.001	3	3
LIVER	GSG1L →	+0.041	+3.584	.005	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 567 associations by consensus.

NIPSNAP1 by MAP1A expression — SKIN

Explore this box plot interactively →