MAOB

Across TCGA pan-cancer cohorts, MAOB Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MAOB data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MAOB Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MAOB expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, OV, and UCEC are the cancer types where MAOB Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.099	0.752	<.001	48	view →
OV	OS	Median	All	0.244	0.690	.006	18	view →
UCEC	DFS	Median	All	0.971	0.623	.008	12	view →
KIRP	OS	Median	All	0.222	0.705	.035	4	view →
LUSC	DFS	Median	All	0.217	0.711	.048	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MAOB–HNSC (OS)

Open the HNSC breakdown →