MAOB

Across TCGA cell cohorts, MAOB mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAOB-associated genes across cancer lineages are PLA2G5, SKOR2, and PRAMEF4. Each is linked with MAOB in more than 1 cancer types. Because this analysis shows association rather than direction, both MAOB-to-partner and partner-to-MAOB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLA2G5 grouped by MAOB-low versus MAOB-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAOB→partner) and Y-score (partner→MAOB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PLA2G5 →	+0.060	+4.523	<.001	.003	3	1
STOMACH	SKOR2 →	+0.023	+5.285	<.001	.003	3	1
STOMACH	PRAMEF4 →	+0.006	+5.285	<.001	.003	3	1
LARGE_INTESTINE	MAGEB4 →	+0.029	+5.415	<.001	.004	3	1
LARGE_INTESTINE	FTHL17 →	+0.081	+5.415	<.001	.004	3	1
LARGE_INTESTINE	STRA8 →	+0.215	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

PLA2G5 by MAOB expression — LUNG_SCLC

Explore this box plot interactively →