MANF

Across TCGA patient cohorts, MANF RNA expression is significantly associated with the protein abundance of many other proteins, with 13,684 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible MANF-associated proteins across cancer lineages are CDCP1, FNDC3B, and PLAUR. Each is linked with MANF in more than 6 cancer types. Because this analysis shows association rather than direction, both MANF-to-partner and partner-to-MANF results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MANF versus CDCP1 in CCRCC, with a Pearson correlation of 0.37.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MANF→partner) and Y-score (partner→MANF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CDCP1 →	+0.813	+0.563	<.001	<.001	3	6
BRCA	FNDC3B →	+0.400	+0.503	.001	.001	3	6
CCRCC	PLAUR →	+0.728	+0.408	.006	.009	2	7
LSCC	PLOD2 →	+0.829	+0.490	<.001	<.001	3	6
GBM	P3H1 →	+0.479	+0.341	<.001	<.001	3	6
GBM	P4HA1 →	+0.575	+0.351	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,684 associations by consensus.

MANF vs CDCP1 — CCRCC

Explore this scatter interactively →