MANF

Across TCGA pan-cancer cohorts, MANF RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated MANF data layer compared with 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MANF RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MANF expression acts as an unfavorable survival marker, although some lineages such as OV and COAD show a favorable association.

HNSC, ACC, and SARC are the cancer types where MANF RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.569	0.728	<.001	64	view →
ACC	DFS	Median	All	0.229	0.657	<.001	57	view →
SARC	DFS	Tertile	All	0.221	0.449	<.001	45	view →
UVM	OS	Median	III,IV	0.281	1.000	.003	44	view →
KIRC	DFS	Quartile	III,IV	0.457	0.733	.002	44	view →
LGG	OS	Median	All	0.851	0.937	<.001	42	view →
LIHC	OS	Tertile	All	0.582	0.771	<.001	39	view →
KIRP	DFS	Tertile	All	0.635	1.000	.003	34	view →
KICH	DFS	Tertile	All	0.718	1.000	.009	29	view →
OV	OS	Median	II,III,IV	0.379	0.279	.002	28	view →
PAAD	DFS	Median	II,III,IV	0.356	0.576	.008	25	view →
SKCM	DFS	Median	III,IV	0.508	0.773	.003	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

MANF–HNSC (DFS)

Open the HNSC breakdown →