MANF

Across TCGA patient cohorts, MANF protein abundance is significantly associated with the RNA expression of many other genes, with 21,048 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MANF-associated genes across cancer lineages are MZB1, IGLV2-23, and IGKV3OR2-268. Each is linked with MANF in more than 6 cancer types. Because this analysis shows association rather than direction, both MANF-to-partner and partner-to-MANF results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MANF versus MZB1 in LSCC, with a Pearson correlation of 0.83.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MANF→partner) and Y-score (partner→MANF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MZB1 →	+1.892	+0.724	<.001	<.001	3	7
HNSC	IGLV2-23 →	+3.223	+0.562	<.001	<.001	3	7
LSCC	IGKV3OR2-268 →	+1.542	+0.610	<.001	<.001	3	7
HNSC	IGHV4-59 →	+3.295	+0.585	<.001	<.001	3	7
LUAD	IGHV3-49 →	+1.905	+0.583	<.001	<.001	3	6
LSCC	IGKV1D-8 →	+1.746	+0.703	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,048 associations by consensus.

MANF vs MZB1 — LSCC

Explore this scatter interactively →