MANF

Across TCGA patient cohorts, MANF mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible MANF-associated genes across cancer lineages are RN7SL763P, MIR3155A, and NPM1P45. Each is linked with MANF in more than 1 cancer types. Because this analysis shows association rather than direction, both MANF-to-partner and partner-to-MANF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL763P grouped by MANF-low versus MANF-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MANF→partner) and Y-score (partner→MANF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL763P →	+0.119	+7.816	<.001	.008	3	1
BLCA	MIR3155A →	+0.498	+4.840	<.001	.002	3	1
BLCA	NPM1P45 →	+0.095	+4.840	<.001	.002	3	1
BLCA	RPS28P1 →	+0.269	+5.914	<.001	<.001	3	1
BLCA	OR6K2 →	+0.039	+5.018	<.001	.004	3	1
BLCA	RNA5SP366 →	+0.256	+5.618	.006	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

RN7SL763P by MANF expression — SKCM

Explore this box plot interactively →