MANF

Across TCGA cell cohorts, MANF RNA expression is significantly associated with the go_rna of many other GO terms, with 3,368 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MANF-associated GO terms across cancer lineages are Regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway, GDP-mannose biosynthetic process, and Positive regulation of early endosome to late endosome transport. Each is linked with MANF in more than 14 cancer types. Because this analysis shows association rather than direction, both MANF-to-partner and partner-to-MANF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway grouped by MANF-low versus MANF-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MANF→partner) and Y-score (partner→MANF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway →	+0.155	+0.578	.006	<.001	2	15
SOFT_TISSUE	GDP-mannose biosynthetic process →	+0.145	+0.725	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Positive regulation of early endosome to late endosome transport →	+0.103	+0.804	.002	.009	3	11
SKIN	Positive regulation of intracellular protein transport →	+0.067	+0.886	<.001	<.001	3	10
BLOOD_Myeloma	Positive regulation of retrograde protein transport, ER to cytosol →	+0.227	+1.116	<.001	<.001	3	10
BLOOD_Myeloma	Multi-pass transmembrane protein insertion into ER membrane →	+0.116	+0.797	.009	.007	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,368 associations by consensus.

Regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway by MANF expression — BONE

Explore this box plot interactively →