Q-omics provides the consensus-scored MANEALP1 profile across patient tissues and cancer cell-line models. MANEALP1 expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, MANEALP1 is differentially expressed in 5, with the highest sampling consensus in THCA. Additionally, MANEALP1 RNA expression shows 6,704 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight ACC, THCA, and STAD as cancer lineages where MANEALP1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MANEALP1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MANEALP1 survival associations across molecular data types. MANEALP1 RNA expression shows survival associations in the most cancer types (20). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MANEALP1 RNA expression–survival associations across cancer types. High MANEALP1 expression shows unfavorable associations in ACC, UVM, LIHC, MESO and DLBC, but favorable associations in PAAD. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for MANEALP1 RNA expression.
This table summarizes MANEALP1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 5. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for MANEALP1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MANEALP1 shows lower tumor expression in THCA, BRCA and KICH and higher tumor expression in KIRC and COAD. The THCA box plot shows higher MANEALP1 RNA expression in normal versus tumor tissue (log2 FC = −0.056, t-test p = .010).
This table shows molecular features associated with MANEALP1 in patient tissues and cancer cell lines. In patient samples, MANEALP1 shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.
