MANEA

Across TCGA pan-cancer cohorts, MANEA mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of MANEA’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where MANEA mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types MANEA is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

PDAC, CCRCC, and HNSC are the cancer types where MANEA tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MANEA mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	All	All	−0.428	<.001	5	view →
CCRCC	All	All	+0.229	<.001	5	view →
HNSC	All	All	+0.229	.005	4	view →
LSCC	Female	All	+0.403	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

MANEA–PDAC

Open the PDAC breakdown →