MANEA

Across TCGA pan-cancer cohorts, MANEA RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated MANEA data layer compared with 7 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MANEA RNA is associated with better overall survival. In most high-consensus cancer types, elevated MANEA expression acts as an unfavorable survival marker, although some lineages such as KIRC and SKCM show a favorable association.

KIRC, SKCM, and LGG are the cancer types where MANEA RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.714	0.548	<.001	107	view →
SKCM	OS	Median	All	0.384	0.284	<.001	58	view →
LGG	OS	Median	All	0.370	0.560	<.001	54	view →
UCS	OS	Median	IV	0.752	0.404	.013	32	view →
COAD	OS	Tertile	II,III,IV	0.832	0.688	.015	27	view →
THYM	DFS	Median	II,III,IV	0.947	0.518	.005	23	view →
KIRP	OS	Quartile	All	0.814	0.945	.013	19	view →
CESC	DFS	Tertile	III,IV	0.274	0.835	.006	16	view →
LIHC	DFS	Tertile	All	0.471	0.612	.002	15	view →
HNSC	OS	Tertile	All	0.291	0.557	.008	12	view →
READ	OS	Median	IV	0.824	0.455	.005	12	view →
PRAD	DFS	Tertile	All	0.925	0.855	.033	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

MANEA–KIRC (OS)

Open the KIRC breakdown →