MANEA

Across TCGA patient cohorts, MANEA protein abundance is significantly associated with the RNA expression of many other genes, with 3,215 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible MANEA-associated genes across cancer lineages are MAPK3, MKRN1, and MED6. Each is linked with MANEA in more than 2 cancer types. Because this analysis shows association rather than direction, both MANEA-to-partner and partner-to-MANEA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MANEA versus MAPK3 in BRCA, with a Pearson correlation of -0.28.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MANEA→partner) and Y-score (partner→MANEA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MAPK3 →	-0.605	-0.532	.002	.002	3	3
OV	MKRN1 →	-0.433	-0.769	.002	.005	3	3
UCEC	MED6 →	-0.441	-0.613	.003	.009	3	3
UCEC	MIDEAS →	-0.584	-0.461	<.001	.004	3	3
BRCA	BRF1 →	-0.449	-0.440	.002	.005	3	3
BRCA	RNF208 →	-0.900	-0.483	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,215 associations by consensus.

MANEA vs MAPK3 — BRCA

Explore this scatter interactively →