MANEA

Across TCGA patient cohorts, MANEA mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MANEA-associated genes across cancer lineages are PCNA, ERK2, and Annexin-1. Each is linked with MANEA in more than 1 cancer types. Because this analysis shows association rather than direction, both MANEA-to-partner and partner-to-MANEA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by MANEA-low versus MANEA-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MANEA→partner) and Y-score (partner→MANEA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	PCNA →	+0.289	+2.179	.003	.035	3	2
UCEC	ERK2 →	+0.177	+2.584	.004	.001	3	2
UCEC	Annexin-1 →	+0.390	+2.584	.022	.010	3	2
UCEC	Cyclin-B1 →	+0.517	+1.716	.004	.003	3	2
LUSC	GSK-3a-b_pS21_S9 →	-0.388	-3.169	.044	.018	3	1
LUSC	Src_pY416 →	-0.400	-3.312	.023	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

PCNA by MANEA expression — LUSC

Explore this box plot interactively →