MANEA

Across TCGA cell cohorts, MANEA RNA expression is significantly associated with the go_rna of many other GO terms, with 3,510 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MANEA-associated GO terms across cancer lineages are 7-methylguanosine mRNA capping, 7-methylguanosine RNA capping, and Regulation of mitotic metaphase/anaphase transition. Each is linked with MANEA in more than 14 cancer types. Because this analysis shows association rather than direction, both MANEA-to-partner and partner-to-MANEA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 7-methylguanosine mRNA capping grouped by MANEA-low versus MANEA-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MANEA→partner) and Y-score (partner→MANEA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	7-methylguanosine mRNA capping →	+0.153	+1.365	<.001	<.001	3	15
LUNG_NSCLC_LUSC	7-methylguanosine RNA capping →	+0.153	+1.365	<.001	<.001	3	15
LUNG_NSCLC_LUSC	Regulation of mitotic metaphase/anaphase transition →	+0.124	+1.051	.006	.006	3	14
OESOPHAGUS	Negative regulation of ubiquitin protein ligase activity →	+0.251	+1.302	<.001	.003	3	13
KIDNEY	Protein localization to kinetochore →	+0.164	+0.995	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Negative regulation of mitotic metaphase/anaphase transition →	+0.182	+1.167	.006	.005	2	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,510 associations by consensus.

7-methylguanosine mRNA capping by MANEA expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →