MANEA

Across TCGA cell cohorts, MANEA mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MANEA-associated genes across cancer lineages are OR10H5, C16orf82, and USP17L17. Each is linked with MANEA in more than 1 cancer types. Because this analysis shows association rather than direction, both MANEA-to-partner and partner-to-MANEA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10H5 grouped by MANEA-low versus MANEA-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MANEA→partner) and Y-score (partner→MANEA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR10H5 →	+0.012	+4.977	<.001	.007	3	1
SKIN	C16orf82 →	+0.016	+4.977	<.001	.007	3	1
STOMACH	USP17L17 →	+0.010	+4.285	<.001	.007	3	1
OVARY	XAGE5 →	+0.255	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

OR10H5 by MANEA expression — SKIN

Explore this box plot interactively →