MANEA-DT

Across TCGA pan-cancer cohorts, MANEA-DT RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated MANEA-DT data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MANEA-DT RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MANEA-DT expression acts as an unfavorable survival marker, although some lineages such as UCS and READ show a favorable association.

KIRC, UCS, and READ are the cancer types where MANEA-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.510	0.704	<.001	90	view →
UCS	DFS	Median	IV	0.952	0.367	.001	74	view →
READ	OS	Median	II,III,IV	0.777	0.470	<.001	47	view →
ESCA	OS	Median	II,III,IV	0.639	0.391	.006	40	view →
SKCM	OS	Quartile	All	0.396	0.273	.003	39	view →
KICH	OS	Quartile	All	0.661	1.000	.006	21	view →
STAD	DFS	Quartile	IV	0.250	0.742	.016	15	view →
HNSC	OS	Median	III,IV	0.518	0.229	.012	14	view →
COAD	OS	Median	IV	0.647	0.420	.022	12	view →
LIHC	DFS	Tertile	All	0.427	0.575	.002	12	view →
THCA	DFS	Quartile	II,III,IV	0.810	0.945	.023	10	view →
KIRP	DFS	Median	All	0.539	0.666	.011	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

MANEA-DT–KIRC (DFS)

Open the KIRC breakdown →