MANEA-DT

Across TCGA pan-cancer cohorts, MANEA-DT RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MANEA-DT’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MANEA-DT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MANEA-DT is over-expressed in tumor, although a few such as UCEC and BRCA show the opposite, repressed pattern.

COAD, HNSC, and UCEC are the cancer types where MANEA-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MANEA-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	+0.193	<.001	8	view →
HNSC	Male	III,IV	+0.202	.005	7	view →
UCEC	All	All	−0.375	.002	6	view →
BRCA	Female	All	−0.267	<.001	6	view →
KIRC	All	All	+0.192	<.001	6	view →
BLCA	All	All	+0.421	.010	4	view →
KICH	All	All	−0.352	<.001	3	view →
CHOL	All	II,III,IV	+0.880	.010	2	view →
LUSC	All	All	+0.224	.004	2	view →
PRAD	All	All	−0.155	.004	2	view →
LIHC	All	All	+0.139	<.001	2	view →
KIRP	Male	II,III,IV	+0.262	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MANEA-DT–COAD

Open the COAD breakdown →