MANBA

Across TCGA pan-cancer cohorts, MANBA mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MANBA data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher MANBA mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MANBA expression acts as an unfavorable survival marker.

PDAC, LUAD, and GBM are the cancer types where MANBA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	III,IV	0.346	0.902	<.001	33	view →
LUAD	DFS	Quartile	All	0.837	1.000	.002	17	view →
GBM	DFS	Tertile	All	0.667	0.815	.020	11	view →
CCRCC	DFS	Quartile	III,IV	0.233	0.887	.038	3	view →
HNSC	DFS	Median	IV	0.920	1.000	.028	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MANBA–PDAC (DFS)

Open the PDAC breakdown →