MANBA

Across TCGA patient cohorts, MANBA mutation is significantly associated with the RNA expression of many other genes, with 4,362 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MANBA-associated genes across cancer lineages are PFKFB4, RNU6-185P, and MTCO1P56. Each is linked with MANBA in more than 2 cancer types. Because this analysis shows association rather than direction, both MANBA-to-partner and partner-to-MANBA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PFKFB4 grouped by MANBA-low versus MANBA-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MANBA→partner) and Y-score (partner→MANBA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PFKFB4 →	+1.392	+2.591	<.001	.006	3	3
BRCA	RNU6-185P →	+0.449	+7.234	<.001	<.001	3	3
COAD	MTCO1P56 →	+0.415	+5.917	<.001	.001	3	3
UCEC	FAM168B →	+0.463	+1.458	<.001	.001	3	2
UCEC	ZUP1 →	+0.384	+3.213	<.001	<.001	3	2
UCEC	ABHD3 →	+0.600	+1.642	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,362 associations by consensus.

PFKFB4 by MANBA expression — SKCM

Explore this box plot interactively →