MANBA

Across TCGA patient cohorts, MANBA mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MANBA-associated genes across cancer lineages are p21, Raptor, and Shc_pY317. Each is linked with MANBA in more than 2 cancer types. Because this analysis shows association rather than direction, both MANBA-to-partner and partner-to-MANBA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p21 grouped by MANBA-low versus MANBA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MANBA→partner) and Y-score (partner→MANBA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p21 →	+0.140	+2.598	.017	.005	3	3
UCEC	Raptor →	-0.104	-1.362	.025	.034	3	2
UCEC	Shc_pY317 →	-0.138	-2.070	.002	.001	3	2
UCEC	4E-BP1_pT37_T46 →	-0.308	-1.752	.007	.011	3	2
UCEC	4E-BP1 →	+0.242	+3.700	.003	.001	3	2
UCEC	14-3-3_beta →	-0.073	-1.673	.017	.040	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

p21 by MANBA expression — UCEC

Explore this box plot interactively →