MAN2A1

Across TCGA pan-cancer cohorts, MAN2A1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MAN2A1 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher MAN2A1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MAN2A1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and COAD show a favorable association.

GBM, CCRCC, and HNSC are the cancer types where MAN2A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Quartile	All	0.332	0.697	<.001	26	view →
CCRCC	OS	Median	All	0.605	1.000	.001	15	view →
HNSC	DFS	Tertile	All	0.839	0.660	.012	12	view →
PDAC	DFS	Median	All	0.329	0.485	.010	7	view →
COAD	DFS	Median	IV	1.000	0.605	.043	6	view →
LUAD	DFS	Quartile	All	0.615	1.000	.021	6	view →
LSCC	OS	Median	All	0.838	0.928	.026	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MAN2A1–GBM (OS)

Open the GBM breakdown →